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Monster Hunter Rise: Sunbreak
2023.06.09 09:41 Gattusso02 Monster Hunter Rise: Sunbreak
 | submitted by Gattusso02 to PSTrophyHuntersPH [link] [comments] https://preview.redd.it/jgcbfg5l4y4b1.jpg?width=1920&format=pjpg&auto=webp&s=0b5564ab5919648f23473b3f0d7c2b397b5928c8 Monster Hunter Rise: Sunbreak Time: 200 hrs + 100% Clear: 400 hrs + Difficulty: 7.5/10 The Monster Hunter franchise returns with the previously Nintendo exclusive finally getting its release on PlayStation. Prepare for one long, grindy and fulfilling ride collecting monster crowns all over again. This guide will now include the massive Sunbreak DLC complete with new monsters and better end game gear to make your platinum or 100% completion more efficient. Trophy Guide Powerpyx Trophy Guide for Monster Hunter Rise Powerpyx Trophy Guide for Monster Hunter Rise: Sunbreak Full credit to Powerpyx for the guides. Wiki Guides https://game8.co/games/Monster-Hunter-Rise https://monsterhunterrise.wiki.fextralife.com/Monster+Hunter+Rise+Wiki Credit to Game8 and Fextralife for the excellent wikis. Game8 has the more comprehensive guide complete with locations on where to farm certain items, along with equipment builds and other very useful information. Best to choose one of those builds as your base and swap out armors and skills along the way to find the build perfect for you. Fextralife has a more tabulated approach on the info that helps you get a quick glance on what you are looking for with lesser clicks but may have only concise information compared to Game8. For example, If you are looking for an item drop from a small monster, Fextralife will show you drop rates and which map to visit for your hunt. Game8 will give you a little more and show you the areas in the map where these small monsters are located. Intro If you're a beginner to the game or the series in general, the beginning sections and tutorials will naturally be quite overwhelming. Take things one step at a time, find a weapon that fits your play style best and enjoy the ride until you get a decent amount of monster hunts in to familiarize yourself with the game. There will be tons of things to tweak and learn about on this game and no single article can give justice to the complexities of how to fully optimize your experience so additional research is recommended. Treat this article as a supplementary guide. Efficiency Tips Enjoy the story and progress through the main quest line as soon and as often as you can. The reason for this is as you progress through the story and your hunter rank increases, more equipment upgrades will be available to you along with the ability to upgrade the base defense of your gear further which unlocks incrementally as you increase in rank. The more defense you have means the more hits you can take and less healing items you consume which you can spend learning the monsters moves and hitting it. Work on the 🏆 Beat-up Construction Kit as soon as possible and unlock all camp site locations on each map so you can fast travel conveniently closer to your target's location. Materials List and Locations can be found here on Game8 to search for your gear and quest requirements. Browse it or simply drop the item you are looking for on the search bar. Blights and Status Ailments Explained and their Cures is explained best in GadgetGabe's Top Voted answer from this GameFAQs forum. Use this wisely to cure yourself ASAP and stay at tip top shape for your fight. You can eventually customize your item load outs when hunting particular monsters. Register an inventory and radial menu layout that is best for your hunt and tweak it accordingly if you are working on a solo hunt or are in a group. You can set up your action bar (the bar that uses the left and right d-pad) too. Learn about monster elemental and ailment weaknesses, weak points and parts that you can sever to improve your success rate in a fight. E.g. Flash bombs work well on monsters in flight. Severing a Pukei-pukei's tail makes the monster incapable of it's wide poison gas attack. Monster Elemental and Ailment Weaknesses and Immunities credit to Pro Game Guides. Monster Hunter Rise explains monster elemental weaknesses well but does not give too much of a description of what elements the monster utilizes against you. To learn that and build the right resistances, refer to the Fextralife MHR Wiki. As you progress through your hunts, make sure to pick up any hunting helpers and golden/gilded spiribugs along the way. You will need 500 and 1000 respectively for the trophies 🏆 Hunting Helpers Plate and 🏆 Golden Spiribug Plate. If you want to farm Spiribugs exclusively, this video shows an excellent route while displaying some skills on speedy map traversal. When you are in town, there will be times when you will be prompted that a sale is ongoing from the two merchants. Always take action on this prompt and participate in the lottery that is only available during this sale to progress towards the 12 room decorations you need to win as part of the 🏆 Sturdy Padlock. If the grand prize of the lottery is a room decoration, you have to roll a Jackpot (different from a Bingo) to win it. Even if the grand prize is not a room decoration, you are given a required room decoration for winning 100 items in the lottery. https://preview.redd.it/umkifupr4y4b1.jpg?width=1280&format=pjpg&auto=webp&s=59415edcabf6cce7231f813358e6ec80bd52d995 https://preview.redd.it/r14333es4y4b1.jpg?width=1640&format=pjpg&auto=webp&s=cacf53afbec816fd78f9567c2dc513e080f83c1d 🏆 Extravagant Cashbox Awarded for earning 1,000,000 Zenny. The fastest method to earn zenny is by participating in the 2 Star Low Rank Event Quest - Gotta Hoard Fast!. It can be done with a group in 1 minute and rewards you with a Golden Egg which you can sell to the merchant for 20,000z. Use whenever you are short on money. This is also the best quest to use if you want to trigger merchant sales quickly and roll on the lottery. Using your silk bind/aerial moves to deliver mount damage (indicated by a blue cloud background on the damage inflicted) is a good tactic to learn and master. Arekkz Gaming's Monster Riding Tutorial video explains this well. You can also scout the area where you mount the monster and bump him into special areas on the map that will deal extra damage. High Rank Quests An Armorcharm and Powercharm will now be available to purchase from the two item merchants. These work as permanent stat increases as long as you have them in your Item Pouch. When you reach HR7, you will eventually be able to upgrade these charms into Armortalon and Powertalon. These stack and you may repurchase Armorcharm and Powercharm and hold all four items in your Item Pouch. Decorations will unlock from the Smithy and the Melding Pot will unlock from the item merchants. This would be a good time to study the skills you have available in conjunction with your armor skills and start creating defensive/offensive load outs based on what you are up against. For talisman crafting via the Melding Pot, craft out the desired skill you need and use accordingly. Once you have your talisman of choice, always roll with Melding - Wisp of Mystery and Melding - Rebirth (unlocks last on a higher HR). They will cost more materials to craft, but will also have better chances of a Rarity 7 Talisman with more skills and better decoration slots. Prepare status resistances/immunities depending on the monsters you are up against and build up defense, elemental defense and even add elemental attack against them as well. Take note that elemental attack increases on skills only increases an existing element on weapons (or elemental ammo for bowguns) and can not create an element from a non-elemental weapon source. For more on elemental damage and elemental resistances, see Fextralife's articles linked accordingly. Armorskin and Demondrug and their corresponding Mega version are items consumed once and will last until you faint or complete the quest. Invest in them as soon as you have the zenny to afford them. You will need to farm Pale Extract from the monster Khezu or purchased as a rare find in the Argosy to craft the mega drugs. You may also choose to deploy the meowcenaries to fight a Khezu to increase your item farm. Master Rank Quests and Sunbreak Content With Sunbreak comes a whole new base map and two new locations to explore. Like the base game, there are a number of trophies that involve you interacting with the townsfolk and the goods and services they have to offer. Refer to this video guide for a checklist of what you need to be doing after every quest to cover the trophies 🏆 Snowy Cohoot Minipouch, 🏆 Secret Honey Jar, 🏆 Unbreakable Bag, 🏆 Solid Padlock, 🏆Polychrome Acorn and 🏆 Sojourn Necklace. 🏆 Solid Padlock requires another set of items you need to win in the lottery but take note that the Gargolda Statue only starts appearing after you take a picture of it. Take a daytime expedition for a photo of the creature. Gamer Guru's video shows you how to do it. Refer to Game8's Eurekacorn article for more ways on farming Eurekacorns for your Polychrome Acorn trophy. Efficiency Tip: Target an expedition with a Herb Node in the Frost Islands together with a Khezu Node for both Eurekacorns and Pale Extracts. For efficient map traversal, unlock the alternative camp sites on the two new Sunbreak areas along with the new buddy recon points. You will have to unlock 2 recon points per map, for a total of 12 for 🏆 Buddy Whistle. Darcblade has an excellent video guide to cover this. Crown Hunting 🏆 Mini Crown Plaque and 🏆 Gold Crown Plaque will most likely be the last trophies you will get in the game as these are very grindy to obtain. These entail slaying or capturing the smallest and largest versions of each monster, awarding you a gold crown on your Hunter's Notes. An alternative grouped view of all your crowns can be found in OPT -> Multiplayer -> Guild Cards -> View -> L1 for Hunting Log. Unlike MH World, Rise does not include a crown notification in the points reward section after a hunt. You will have to check your Hunter Notes manually. You do get a prompt of "Monster Size Updated" right after the kill or capture though as your best indicator of a possible crown. Crown Hunting Tips and Drop Rates explained by Luke Albigés of TrueAchievements Efficient Strategy You will want to clear out all the crowns you can possibly obtain from the quests with the 100% chance or boosted crown rate quests. For everything else, learn how to crown snipe to save time and not waste too much time on normal sized targets. If your are sure that your target monster is not a crown size, abort your quest and start a new one. Take note that you need to capture/kill 10 monsters of each type for their respective monster scroll to progress on your 🏆 Sturdy Padlock so anything close to a perceived small or large crown would be worth the kill. The Sunbreak Expansion and Master Rank buffs up the crown monsters appearance rate to as high as 10% for large and 6% for minis. You are best saving the crown hunt for last as you have to tackle Anomaly Investigations for the Sunbreak 🏆 Bahari's Hand Wound Birdie, which entails you earning and spending 3000 Investigation Coins as rewards for these type of quests along with clearing out every single Master Rank quest for the 🏆 Record of Utmost Valor - Master and clearing out 1-4 star anomaly quests for the 🏆 Painting - Crimson Nightmare. There are a total of 7 1-star anomaly quests to unlock and 8 quests for 2-4 stars. There is a good chance that you will be earning majority of these crowns along your progression towards these three trophies with minimal crown cleanup. Videos for Monster Measurements As of this writing, there seems to be a lack of content on Large and Mini Gold Crowns for MH Rise. Below is video clips to give some clues on how these monster sizes will look when you encounter them. Monster sizes with 100% chance drop quests will be excluded from this segment. Kiranico has an excellent large monster guide which also displays the recommended quest to participate in with corresponding crown percentages. Anomaly Investigation quest monsters have fixed sizes and will never yield any crowns. The normal Anomaly Quests will share the same 6% small and 10% large crown chance as the MR quests. Base Game Crowns Anjanath Mini Gold Crown Barioth Large Gold Crown Barioth Mini Gold Crown Barroth Mini Gold Crown Chameleos Large Gold Crown Chameleos Mini Gold Crown Great Izuchi Large Gold Crown Great Izuchi Mini Gold Crown Ku-Lu-Yaku Large Gold Crown Ku-Lu-Yaku Mini Gold Crown Kushala Daora Mini Gold Crown Lagombi Large Gold Crown Rakna-Kadaki Large Gold Crown Rathalos Mini Gold Crown Royal Ludroth Large Gold Crown Teostra Large Gold Crown Teostra Mini Gold Crown Sunbreak Crowns There are only 16 additional monsters tied up to the crown trophies for Sunbreak which are the monsters that were available at the original release of the game. You will need these 16 monsters along with all the base game crowns for the 🏆 Miniature Crown Shield and 🏆 Gold Crown Shield to unlock. Refer to the Gold Crown Shield segment of Powerpyx's guide for the full list. Astalos Large Gold Crown Aurora Somnacanth Mini Gold Crown Gore Magala Large Gold Crown Malzeno Large Gold Crown Pyre Rakna-Kadaki Large Gold Crown Scorned Magnamalo Large Gold Crown Miscellaneous Grind 🏆 Antique Bookmark Achieved by collecting all 60 Relics scattered over the 5 available maps. Powerpyx's guide for all Relic Locations shows these well. There is a correction to the linked article however, as it is mentioned there that the Rampage Relics unlock after collecting all 10 other Relics per map but is incorrect (unsure what triggers rampage Relic availability but I had access to them at 5 star quest availability on Village and Hub quests). To track the relics you have collected already, go to OPT -> Info -> Hunter Notes -> Notebook. Gaming with Abyss has good Monster Hunter trophy content and shows locations of each relic per map clearly on his videos. Shrine Ruins Frost Islands Flooded Forest Sandy Plains Lava Caverns Other Useful Information Affinity vs Raw Damage is discussed well on this steamcommunity forum. The difference between KO/Stun and Trip is explained will in this article. Note that KO and Stun status are the same (in game and articles call it one or the other so this can be confusing) but Trip status is different. Critical Boost at level 1 raises damage dealt by critical hits by 5%. Your critical hits are already at a base amplified damage of 25% (not mentioned in-game). This could be deceiving due to the in-game skill definition. Palamutes and Palicos you bring on the hunt increase your ease and efficiency and are best slotted with the best gear for your playstyle. Game8 has an excellent buddy guide that discusses end game builds. Use the Basic behavior if you are running a melee focused buddy and Follow if you are using a ranged buddy. This is discussed thoroughly by CheaterMcCheat. On solo hunts, don't let the common combo of 1 Palico and 1 Palamute mold you to run with that as there are several builds that utilize 2 Palicos or 2 Palamutes in one hunt. For example, you may want to use a double Palamute with C Jelly Travel Bag X weapon on the Best Equipment For Sunbreak (Ranged)segment. Accompanied with the Palamute Silkbinder, this build can provide excellent monster control. Ordering Motley Mixes in the canteen nets you dango tickets as a reward. Claim it from the chef after some orders and use the tickets with hopping skewers on your harder hunts. Latent Power skill is triggered by an internal timer upon monster encounter and attack animations and is explained here on Fextralife's wiki. Auto-shoutouts are useful for your party and even yourself. You can program these auto shoutouts via OPT -> Multiplayer -> Chat Menu -> Triangle and click on the field under Text to program what you want to shout-out, choose the box under speech timing to choose the condition. These conditions aren't fixed and you have more to choose from. The most useful ones are the auto shoutouts for "When you set a trap" and "When a monster is limping" where the monster enters the blue icon state and is capturable if it is not an elder, apex or afflicted monster. Weapon Specific Notes Light Bowgun Light Bowgun Basic Moves and Ammo Types credit to Phemeto Pay attention to the color of your reticle. An orange reticle tells you that your ammo type is in its ideal range and will deal its intended damage. A yellow reticle means your shots will hit, but will be significantly weaker. The Fanning Vault Silkbind skill is best used with your Wyvernblast special ammo. Press circle while you are directly under the monster to plant a bomb directly on it. You will be replacing this with the Switch Skill Fanning Maneuver for end game builds. Ammo Details can be found by going to Items and Equipment (opt button) -> Equipment Info -> Ammo Details (square) You will normally run out of your full magazine of your most desired ammo. To minimize returning to camp, bring the materials you need to craft that ammo and set it on your radial menu. Also, avoid bringing the ammo type you never use to keep your ammo menu as decluttered as possible for efficient ammo switching. It is encouraged to bind the ammo you use and their craft commands in your radial menu as well. Recoil is the delay between firing shots (different from Reload delay). Lower recoil = Faster Attack Speed Deviation is the drift of the bullets when you fire. If you have a weapon with deviation, it will travel center for a medium distance then swerve to the L or R depending on the strength of the deviation. Targeting "No deviation" is ideal. Decorations can be crafted to reduce Reload, Recoil and Deviation. Light Bowgun Weapon & Armor Skills Bombardier skill does not work with any ammos, including sticky, cluster, or wyvernblast. Normal/Rapid Up skill improves Normal Ammo damage by 5%/10%/20% and stacks with the skill Rapid Fire Up which enhances rapid fire damage also by 5%/10%/20% Great Sword Recommended Switch Skills are Tackle, Rage Slash (RS), and Adamant Charged Slash (ACS). All three can tank monster attacks (no knockbacks) and negates roar effects. Tackle is the bread and butter during roars and quick monster attacks since its easy to trigger, You can use Adamant Charged Slash for positioning, and Rage Slash to land your last charged attack on your desired direction, which True Charged Slash Skill cant do. How to Unlock: Adamant Charged Slash - Unlocked by crafting/upgrading 8 different Greatswords, no duplicates. Replaces the Hunting Edge skill. Rage Slash - Unlocked by completing the quest "Grasp the Greatsword" (HR5 Quest). Replaces the True Charged Slash skill. Low Rank Entry GS - Crit Eye Build Low Rank GS - Crit Draw Build - 80% Affinity on Overhead and Charged Slash High Rank GS Build - 90% Affinity on Weakpoints + Focus 3 Several members of the PSTHPH team contributed to the making of this guide. There is an ongoing issue with this article preventing further edits. Please check the comments for more. |
2023.06.08 21:18 Pomme-M Scientists find the IL-17 protein plays a key role in skin aging
“The study, which was led by Dr. Guiomar Solanas, Dr. Salvador Aznar Benitah, both at the Institute for Research in Biomedicine IRB Barcelona, and Dr. Holger Heyn, at the National Center for Genomic Analysis CNAG, highlights an IL-17-mediated ageing process to an inflammatory state.
Skin ageing is characterised by a series of structural and functional changes that gradually contribute to the deterioration and fragility associated with age. Aged skin has a reduced capacity to regenerate, poor healing ability, and diminished barrier function. Published in the journal Nature Aging, this work describes the changes undergone by different types of cells with ageing and identifies how some immune cells in the skin express high levels of IL-17.
“Our results show that IL-17 is involved in various functions related to ageing. We have observed that blocking the function of this protein slows down the appearance of various deficiencies associated with ageing skin. This discovery opens up new possibilities for treating some of the symptoms or facilitating skin recovery after surgery, for example,” explains Dr. Aznar Benitah, ICREA researcher and head of the Stem Cells and Cancer laboratory at IRB Barcelona.
“Single cell sequencing has allowed us to dive deep into the complexity of cell types and states forming the skin and how these change during lifespan. We did not only find differences in the composition of aged skin, but also changes in cell activity states. Particularly immune cells showed specific age-related profiles, which we could pinpoint by analyzing thousands of individual cells on at a time,” says Dr. Holger Heyn, head of the Single Cell Genomics laboratory at CNAG.
The study describes how, during ageing, the presence of some of these immune cells, namely gamma delta T cells, innate lymphoid cells, and CD4+ T cells, significantly increases in the skin. These same cells also start expressing very high levels of the pro-inflammatory cytokine IL-17.
"Ageing is associated with mild but persistent inflammation and, in the skin, this is characterised by a significant increase in IL-17, which causes skin deterioration," explains Dr. Paloma Solá, first author of the paper, together with Dr. Elisabetta Mereu, who is now a researcher at the Josep Carreras Leukemia Research Institute.
Reversing the symptoms of ageing in skin
Previous studies had described that IL-17 is related to some autoimmune skin diseases, such as psoriasis, and there are existing treatments that block this protein. The team of researchers studied the response of various aspects to blocking IL-17 activity, including hair follicle growth, transepidermal water loss, wound healing, and genetic markers of ageing. These four parameters showed an improvement after treatment, as the acquisition of these ageing traits was significantly delayed.
“IL-17 protein is essential for vital body functions, such as defense against microbes and wound healing, so permanently blocking it would not be an option. What we have observed is that its temporary inhibition offers benefits that could be of interest at a therapeutic level,” says Dr. Guiomar Solanas, associate researcher at IRB Barcelona.
Future work by the researchers will focus on clarifying the ageing processes that are related to inflammatory states in the skin and how these are linked to IL-17. The team will also address whether IL-17 is involved in the ageing and deterioration of other tissues and organs.
This research has received funding from the European Research Council (ERC), the Government of Catalonia, the Spanish Ministry of Science and Innovation, the Lilliane Bettencourt Foundation, the State Research Agency (AEI), and the European Regional Development Fund (ERDF).
Related article:Local IL-17 orchestrates skin agingPaloma Solá*, Elisabetta Mereu*, Júlia Bonjoch^, Marta Casado-Pelaez^, Neus Prats, Mònica Aguilera, Oscar Reina, Enrique Blanco, Manel Esteller, Luciano Di Croce, Holger Heyn#, Guiomar Solanas# and Salvador Aznar Benitah#”Nature Aging (2022) DOI: 10.1038/s43587-023-00431-z
Targeting lymphoid-derived IL-17 signaling to delay skin aging https://www.nature.com/articles/s43587-023-00431-z
Source https://www.irbbarcelona.org/en/news/scientific/il-17-protein-plays-key-role-skin-ageing
submitted by Pomme-M to Psoriasis [link] [comments]
Skin ageing is characterised by a series of structural and functional changes that gradually contribute to the deterioration and fragility associated with age. Aged skin has a reduced capacity to regenerate, poor healing ability, and diminished barrier function. Published in the journal Nature Aging, this work describes the changes undergone by different types of cells with ageing and identifies how some immune cells in the skin express high levels of IL-17.
“Our results show that IL-17 is involved in various functions related to ageing. We have observed that blocking the function of this protein slows down the appearance of various deficiencies associated with ageing skin. This discovery opens up new possibilities for treating some of the symptoms or facilitating skin recovery after surgery, for example,” explains Dr. Aznar Benitah, ICREA researcher and head of the Stem Cells and Cancer laboratory at IRB Barcelona.
“Single cell sequencing has allowed us to dive deep into the complexity of cell types and states forming the skin and how these change during lifespan. We did not only find differences in the composition of aged skin, but also changes in cell activity states. Particularly immune cells showed specific age-related profiles, which we could pinpoint by analyzing thousands of individual cells on at a time,” says Dr. Holger Heyn, head of the Single Cell Genomics laboratory at CNAG.
Immune cells, inflammation, and ageing
In addition to a wide variety of epithelial cells, hair follicle cells, and other components, the skin is also home to immune cells, which play a crucial role in preventing infection and protecting against different damages.The study describes how, during ageing, the presence of some of these immune cells, namely gamma delta T cells, innate lymphoid cells, and CD4+ T cells, significantly increases in the skin. These same cells also start expressing very high levels of the pro-inflammatory cytokine IL-17.
"Ageing is associated with mild but persistent inflammation and, in the skin, this is characterised by a significant increase in IL-17, which causes skin deterioration," explains Dr. Paloma Solá, first author of the paper, together with Dr. Elisabetta Mereu, who is now a researcher at the Josep Carreras Leukemia Research Institute.
Reversing the symptoms of ageing in skin
Previous studies had described that IL-17 is related to some autoimmune skin diseases, such as psoriasis, and there are existing treatments that block this protein. The team of researchers studied the response of various aspects to blocking IL-17 activity, including hair follicle growth, transepidermal water loss, wound healing, and genetic markers of ageing. These four parameters showed an improvement after treatment, as the acquisition of these ageing traits was significantly delayed.
“IL-17 protein is essential for vital body functions, such as defense against microbes and wound healing, so permanently blocking it would not be an option. What we have observed is that its temporary inhibition offers benefits that could be of interest at a therapeutic level,” says Dr. Guiomar Solanas, associate researcher at IRB Barcelona.
Future work by the researchers will focus on clarifying the ageing processes that are related to inflammatory states in the skin and how these are linked to IL-17. The team will also address whether IL-17 is involved in the ageing and deterioration of other tissues and organs.
This research has received funding from the European Research Council (ERC), the Government of Catalonia, the Spanish Ministry of Science and Innovation, the Lilliane Bettencourt Foundation, the State Research Agency (AEI), and the European Regional Development Fund (ERDF).
Related article:Local IL-17 orchestrates skin agingPaloma Solá*, Elisabetta Mereu*, Júlia Bonjoch^, Marta Casado-Pelaez^, Neus Prats, Mònica Aguilera, Oscar Reina, Enrique Blanco, Manel Esteller, Luciano Di Croce, Holger Heyn#, Guiomar Solanas# and Salvador Aznar Benitah#”Nature Aging (2022) DOI: 10.1038/s43587-023-00431-z
Targeting lymphoid-derived IL-17 signaling to delay skin aging https://www.nature.com/articles/s43587-023-00431-z
Source https://www.irbbarcelona.org/en/news/scientific/il-17-protein-plays-key-role-skin-ageing
2023.06.08 16:38 tepidxeyes UVB light therapy
Hi :) I'm a newbie to the community but a seasoned vet to psoriasis. I've been diagnosed for 15+ years and at my worst 80% of my body was covered in thick plaques. Fast forward to today I'm a 36 y/o female with 100% skin clearance thanks to Cosentyx.
Back to the question at hand- uvb light therapy. I've never tried it, so I don't really know how it works. Does it only work on active leisons or does it help in keeping it away as well?
submitted by tepidxeyes to Psoriasis [link] [comments]
Back to the question at hand- uvb light therapy. I've never tried it, so I don't really know how it works. Does it only work on active leisons or does it help in keeping it away as well?
2023.06.07 21:51 Slusho64 Best toothbrush, toothpastes, floss, and mouthwash? I'm seeing conflicting info.
I'm researching and getting conflicting results:
Toothbrushes:
This post states that rotating electric toothbrushes get rid of a third more plaque but wear away at teeth 4-5x more. So which should I use? Do toothbrushes really wear away teeth?
Toothpaste:
I'm seeing Sensodyne Repair and Protect (EU/Canadian) is really good but this listing has a different active ingredient (Sodium Fluoride) on the box than this listing (monofluorophosphate). What's up with that? Both are the version with NovaMin. Also, despite saying that Stannous Fluoride provides antibacterial effects, a poster in this thread uses Sensodyne with NovaMin in the AM and ClinPro 5000 (1.1% Sodium Fluoride) in the PM. Is there something in either of these two toothpastes that is antibacterial or are they forgoing that? Is Stannous Fluoride bad since it can cause stains? What combination should I use?
Floss: I've used Listerine Gentle Gum Care woven floss because it tends to make my gums bleed less and found out it's been discontinued. I see there are a few thicker options like GUM Expanding Floss, Xlent, and COCOFLOSS. Do these work better than standard? I also use a Listerine Ultraclean Access Flosser to reach the back teeth.
Mouthwash: I use ACT Mouthwash after brushing but now I'm seeing suggestions to spit out toothpaste and not rinse. So is mouthwash a bad idea because the specialty toothpastes are a higher concentration of fluoride?
Is there anything else I should be using in my routine?
submitted by Slusho64 to askdentists [link] [comments]
Toothbrushes:
This post states that rotating electric toothbrushes get rid of a third more plaque but wear away at teeth 4-5x more. So which should I use? Do toothbrushes really wear away teeth?
Toothpaste:
I'm seeing Sensodyne Repair and Protect (EU/Canadian) is really good but this listing has a different active ingredient (Sodium Fluoride) on the box than this listing (monofluorophosphate). What's up with that? Both are the version with NovaMin. Also, despite saying that Stannous Fluoride provides antibacterial effects, a poster in this thread uses Sensodyne with NovaMin in the AM and ClinPro 5000 (1.1% Sodium Fluoride) in the PM. Is there something in either of these two toothpastes that is antibacterial or are they forgoing that? Is Stannous Fluoride bad since it can cause stains? What combination should I use?
Floss: I've used Listerine Gentle Gum Care woven floss because it tends to make my gums bleed less and found out it's been discontinued. I see there are a few thicker options like GUM Expanding Floss, Xlent, and COCOFLOSS. Do these work better than standard? I also use a Listerine Ultraclean Access Flosser to reach the back teeth.
Mouthwash: I use ACT Mouthwash after brushing but now I'm seeing suggestions to spit out toothpaste and not rinse. So is mouthwash a bad idea because the specialty toothpastes are a higher concentration of fluoride?
Is there anything else I should be using in my routine?
2023.06.07 15:37 definingcriteria Is my fatigue due to psoriasis or long COVID ? Please advice
I developped mild psoriasis 10 years ago (at the age of 20)
It started on my hands with plaques, itchy skin and dryness. Then it moved to my knees and feet.
2,5 years ago I started to develop chronic fatigue, anxiety, insomiia, GI issues, brain fog, tremors, light/noise sensitivity etc.. after a viral infection that I suspect was covid.
Today most of those issues are gone and I am left with chronic debilitating fatigue and brain fog. I am not able to exercise again and I have put 14kg on. My psoriasis flared many times and is constant now since those 2 years.
My question is : is it remaining symptoms of long covid or is my fatigue due to psoriasis ? Is there a way to know ?
Thank you !
submitted by definingcriteria to PsoriaticArthritis [link] [comments]
It started on my hands with plaques, itchy skin and dryness. Then it moved to my knees and feet.
2,5 years ago I started to develop chronic fatigue, anxiety, insomiia, GI issues, brain fog, tremors, light/noise sensitivity etc.. after a viral infection that I suspect was covid.
Today most of those issues are gone and I am left with chronic debilitating fatigue and brain fog. I am not able to exercise again and I have put 14kg on. My psoriasis flared many times and is constant now since those 2 years.
My question is : is it remaining symptoms of long covid or is my fatigue due to psoriasis ? Is there a way to know ?
Thank you !
2023.06.07 10:58 bayouboho Are comorbidities worth diagnosing?
Social media has been filling my feed with all kinds of stuff this month about ADHD + fibromyalgia, POTS, connective tissue disorders, hypermobility, IBS/IBD, psoriasis, even being tongue tied, etc.
Is it worth mentioning to my doctor any of this? Like, if I’ve made it this long without dying from it, it’s probably fine, right? ….right?
I’ve had IBS since middle school (complete with vasovagal syncope—yay which was brought up to docs numerous times growing up, but I never took a dump in front of my doctor so I never fainted on the toilet in front of my doctor, and since they never SAW it happen, they assumed my mom and I were just being dramatic).
I was diagnosed with fibromyalgia in early college, took meds off and on and ultimately decided they just weren’t right for me after a few years.
My SIL was diagnosed with dysautonomia a few years back and all the symptoms she struggles with, I noticed I’ve experienced since I was a child—most notably the intolerance to temp changes and getting overheated at the drop of a hat (then being stuck feeling like garbage with a nasty headache the rest of the day).
I’ve always had dizziness/tunnel vision when standing after sitting a while. I’ve just learned to be really mindful of my posture and movements, like knowing better than to bend down to tie a kindergartener’s shoe at school or else I may start to black out upon standing and land on top of the poor child.
Today I made sure to check my heart rate on my Apple Watch every time I felt dizzy (aka every time I’ve stood up) and it’s jumping to 120-130+ bpm immediately when standing up from resting position.
If my blood pressure gets weird and suddenly drops, I know to just find a place to sit ASAP and remain completely still until it passes so that I don’t lose consciousness (especially in public—ain’t no strangers calling an ambulance for me to spend the rest of my life paying off!).
I am hypermobile, but not to the extreme of suffering dislocations or anything.
My tongue tie was never corrected as a child (though, my scary dentist always mentioned that and my upper lip frenum at every appointment and said he could get rid of my lisp if my mom gave permission to snip them…how terrifying as a child lol), but I’ve learned to compensate for my lisp. I do live with TMJ and a terribly audible popping sound in my jaw when I eat or chew gum now…wonder if they’re related.
I guess what I’m saying is…isn’t it kind of weird to just drop all this on my doctor now after dealing with it most of my life?? Would diagnosing anything really help, or just give me more doctors to see?
Only thing I’m currently treated for is psoriasis and ADHD, because while I can for the most part mask all the other symptoms, having noticeable bald spots and plaques all over my scalp and eyebrows was affecting my life enough to say something about, lol. Hmm maybe I should mention the heart rate and dizziness thing…
submitted by bayouboho to ADHD [link] [comments]
Is it worth mentioning to my doctor any of this? Like, if I’ve made it this long without dying from it, it’s probably fine, right? ….right?
I’ve had IBS since middle school (complete with vasovagal syncope—yay which was brought up to docs numerous times growing up, but I never took a dump in front of my doctor so I never fainted on the toilet in front of my doctor, and since they never SAW it happen, they assumed my mom and I were just being dramatic).
I was diagnosed with fibromyalgia in early college, took meds off and on and ultimately decided they just weren’t right for me after a few years.
My SIL was diagnosed with dysautonomia a few years back and all the symptoms she struggles with, I noticed I’ve experienced since I was a child—most notably the intolerance to temp changes and getting overheated at the drop of a hat (then being stuck feeling like garbage with a nasty headache the rest of the day).
I’ve always had dizziness/tunnel vision when standing after sitting a while. I’ve just learned to be really mindful of my posture and movements, like knowing better than to bend down to tie a kindergartener’s shoe at school or else I may start to black out upon standing and land on top of the poor child.
Today I made sure to check my heart rate on my Apple Watch every time I felt dizzy (aka every time I’ve stood up) and it’s jumping to 120-130+ bpm immediately when standing up from resting position.
If my blood pressure gets weird and suddenly drops, I know to just find a place to sit ASAP and remain completely still until it passes so that I don’t lose consciousness (especially in public—ain’t no strangers calling an ambulance for me to spend the rest of my life paying off!).
I am hypermobile, but not to the extreme of suffering dislocations or anything.
My tongue tie was never corrected as a child (though, my scary dentist always mentioned that and my upper lip frenum at every appointment and said he could get rid of my lisp if my mom gave permission to snip them…how terrifying as a child lol), but I’ve learned to compensate for my lisp. I do live with TMJ and a terribly audible popping sound in my jaw when I eat or chew gum now…wonder if they’re related.
I guess what I’m saying is…isn’t it kind of weird to just drop all this on my doctor now after dealing with it most of my life?? Would diagnosing anything really help, or just give me more doctors to see?
Only thing I’m currently treated for is psoriasis and ADHD, because while I can for the most part mask all the other symptoms, having noticeable bald spots and plaques all over my scalp and eyebrows was affecting my life enough to say something about, lol. Hmm maybe I should mention the heart rate and dizziness thing…
2023.06.07 09:19 oneuglyducky [Routine Help] I used an acid to exfoliate that was WAY too harsh for my extremely dry and sensitive skin- my psoriasis plaques have been burning an extreme amount for weeks now- how do I fix?
I fucked up really bad.
submitted by oneuglyducky to SkincareAddiction [link] [comments]
2023.06.07 07:18 House_Aves topical pde4 inhibitor - Zoryve cream . Ask for a sample from your derm if you are looking for a non-steroid
I am on a biologic but still have a few small psoriasis spots. I was given sample of this med and find it to be helpful , so I wanted to share . It can be used as maintenance, and doesn’t contain steroids . It can be comfortably used in sensitive areas like the groin as well . It’s a newer med , so I wanted to get this on peoples radar if they are looking for a topical to try .
https://www.newswire.ca/news-releases/steroid-free-next-generation-topical-cream-zoryve-tm-approved-by-health-canada-to-treat-plaque-psoriasis-anywhere-on-the-body1-887101967.html
submitted by House_Aves to Psoriasis [link] [comments]
https://www.newswire.ca/news-releases/steroid-free-next-generation-topical-cream-zoryve-tm-approved-by-health-canada-to-treat-plaque-psoriasis-anywhere-on-the-body1-887101967.html
2023.06.07 05:25 FuelGold2644 does the sun and salt water clear your psoriasis ?
i’m a new yorker who does better down south for a handful of reasons. the major one being i have multiple sclerosis and my body agrees with the heat better than it does the cold. i didn’t get psoriasis until after i gave birth. i never had any sort of skin condition prior to pregnancy either. ever since giving birth march/2022, my psoriasis has been constant and very “alive” until we went on vaca. we went back to charleston and spent ten days in the sun and on the water and my psoriasis was completely cleared. knees, elbows, legs, butt, scalp…all of it. stress levels were down, sky’s were blue with the sun shining, the ocean water had that salty cure 🫶🏻
does this work for anyone else ? i’ve been back in new york for a month now and it’s back. my knees are plaqued up and my elbows are flaking.
submitted by FuelGold2644 to Psoriasis [link] [comments]
does this work for anyone else ? i’ve been back in new york for a month now and it’s back. my knees are plaqued up and my elbows are flaking.
2023.06.06 16:31 Consistent_Week4767 Psoriasis, Eczema, or Allergies?
I’m curious whether anyone has a similar experience to me. My dermatologist thinks I have a mix of psoriasis, eczema, and possibly an allergy. I was on Otezla for about 4 months. It completely got rid of my rashes on my body that were like eczema rashes, but it didn’t do much for my scalp or facial psoriasis. I switched to Skyrizi more than 2 months ago, and have taken both started doses. I haven’t had any results yet. Instead, my body rashes have come back, my face completely swelled up (like an allergic reaction), and I now have plaques all over my face. My dermatologist now wants to switch me to Dupixent. I’m wondering if anyone has had this type of experience. I was so excited to start Skyrizi based on everyone’s experiences but now I just feel like I’m at square one again.
submitted by Consistent_Week4767 to Psoriasis [link] [comments]
2023.06.05 22:41 boobumblebee chances of getting meds on my first visit to a derm?
I have my first derm appointment this week, and really want to push for some medication.
I have psoriasis all over my scalp, and its been getting worse and onto my face and into my ears. Its constantly painful and either dry and itchy or red and raw from peeling.
and it took me 2 months to get a dermatologist appointment, and really want to push to see if I can get some medication like otezla or others.
is this likely, or am I expecting too much?
submitted by boobumblebee to Psoriasis [link] [comments]
I have psoriasis all over my scalp, and its been getting worse and onto my face and into my ears. Its constantly painful and either dry and itchy or red and raw from peeling.
and it took me 2 months to get a dermatologist appointment, and really want to push to see if I can get some medication like otezla or others.
is this likely, or am I expecting too much?
2023.06.05 19:35 r3crac BANGGOOD Deals (5.6.2023)!
BANGGOOD Deals Compilation (5.6.2023)!
Check products in compilation image: https://i.imgur.com/TPCtfob.jpeg or https://i.ibb.co/1bRLVJ918a1b5f4ac6.jpg
-1- GUUDGO Wireless Door Windows Detector Sensor 433MHz
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-2- 125cm Metal Buckle Tactical Belt
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-3- MESTEK TS02A Pen Type Multimeter
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-4- CVJ Demon Wired Earphones
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-5- Unisex Polyester Casual Outdoor Breathable Brim Bucket Hat
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-6- AirAux AA-UM13 Bluetooth V5.1 Earphones
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-7- Stickdrive CLASS10 U3 128G Micro SD Card
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-8- BlitzWolf BW-CML2 Air Monitor Light Bar
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-10- Skylion H600 Wired Gaming Keyboard Mouse Set
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-11- ELEGIANT SR800 Computer Speakers 2.1 [EU]
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-14- Microdrive Class 10 TF Card 256GB SD Card
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-15- Lenovo XT60 TWS Earbuds BT5.3
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-25- Lenovo H3 Wired Headphones 50mm
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-31- Lenovo H5 Gaming Wired Headphones 50mm
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-32- SKYLOONG GK64X GK64XS Keyboard Kit Dual Mode
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-35- Eachine EC35 RTR Flameline 1/14 RC Car with 2 Batteries
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-36- Eachine EC35 RTR Flameline 1/14 RC Car with 2 Batteries [EU]
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-39- GuliKit KingKKong 2 Pro Bluetooth Game Controller
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-70- BEZIOR XF005 16Ah 6.4Ah 500Wx2 Electric Bicycle [EU]
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Products compilation image: https://i.imgur.com/TPCtfob.jpeg or https://i.ibb.co/1bRLVJ918a1b5f4ac6.jpg
submitted by r3crac to couponsfromchina [link] [comments]
Check products in compilation image: https://i.imgur.com/TPCtfob.jpeg or https://i.ibb.co/1bRLVJ918a1b5f4ac6.jpg
-1- GUUDGO Wireless Door Windows Detector Sensor 433MHz
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-2- 125cm Metal Buckle Tactical Belt
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-3- MESTEK TS02A Pen Type Multimeter
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-4- CVJ Demon Wired Earphones
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-5- Unisex Polyester Casual Outdoor Breathable Brim Bucket Hat
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-6- AirAux AA-UM13 Bluetooth V5.1 Earphones
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-7- Stickdrive CLASS10 U3 128G Micro SD Card
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-8- BlitzWolf BW-CML2 Air Monitor Light Bar
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-10- Skylion H600 Wired Gaming Keyboard Mouse Set
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-14- Microdrive Class 10 TF Card 256GB SD Card
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-15- Lenovo XT60 TWS Earbuds BT5.3
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-16- Outdoor Shower Bathroom Shelter [EU]
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-17- Xiaovv V380pro HD 2MP WIFI IP Camera
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-18- 4DRC G6 260mm RC Airplane RTF with 2 Batteries
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-19- Lenovo TS32 6W Bluetooth V5.0 Soundbar
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-22- MUSTOOL X1 Clamp Meter
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-36- Eachine EC35 RTR Flameline 1/14 RC Car with 2 Batteries [EU]
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-39- GuliKit KingKKong 2 Pro Bluetooth Game Controller
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-40- SCULPFUN S10 Engraving Expansion Kit 950x400mm
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-44- MUSTOOL MDS8207 Multimeter Oscilloscope [EU/CZ]
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-45- N-ONE NPad S MT8183 4/64GB 10.1 Inch Android 12 Tablet [EU]
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-49- XIAOVV 4CH 3MP Security Camera System H.265+ P2P 5X Zoom [EU]
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-51- 10.1 inch LCD HD Video Microscope 150X
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-52- JUREN DZ-1BCW 1L Oxygen Concentrator
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-53- FR2000C+ 0.01-1200ohm Clamp Ground Resistance Tester
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-54- Ulefone Armor 21 8/256GB G99
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-58- KUGOO KIRIN M4 Pro 16Ah 48V 500W 10in Electric Scooter [EU]
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-59- GEEKCREIT ATOMSTACK S20 Pro 20W Laser Engraver
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-60- ATOMSTACK A20 Pro Quad-Laser Engraving Cutting Machine [EU]
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-61- SAMEBIKE SY26-FT 10Ah 36V 350W 26 Inches Electric Bike [EU]
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-62- FAFREES-26 Hailong One 36V 10Ah 250W 26in Electric Bicycle [EU]
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-63- NVISEN GX01 Pro i9-10885H GTX 1650Ti 16/512GB Mini PC
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-64- KAISDA K7 36V 12.5Ah 350W 20inch Electric Bicycle [EU]
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-65- PHILODO H4 250W 48V 13Ah 20x4inch Electric Bicycle [EU]
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-66- GOGOBEST GM26 36V 10Ah 250W Electric Bicycle [EU]
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-67- FENGMI VX 4K Projector DLP 240Hz
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-68- GOGOBEST GF750 17.5Ah 2000W Electric Bicycle [EU]
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-69- GOGOBEST GF650 48V 20Ah 1000W 26X4.0inch Electric Bicycle [EU]
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-70- BEZIOR XF005 16Ah 6.4Ah 500Wx2 Electric Bicycle [EU]
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Products compilation image: https://i.imgur.com/TPCtfob.jpeg or https://i.ibb.co/1bRLVJ918a1b5f4ac6.jpg
2023.06.05 03:39 Snakecharmer119 Plaque psoriasis on/off for 52 years, first experience with Guttate and it is STUBBORN!
What can cause Guttate flares other than strep? I have had plaque psoriasis for 52 years. My first Guttate flare began a few months ago. I'd categorize it as mild to moderate - it isn't as widespread as many cases I've read about. I'm baffled because I was tested for strep and a few other things and everything came back normal.
I can't get into a doctor for several months and I guess right now I'm just curious re: what others have experienced. Because I have to wait a few months to see a Dr, I decided to remove gluten, dairy, and nightshades again to see if it helps at all.
submitted by Snakecharmer119 to Psoriasis [link] [comments]
I can't get into a doctor for several months and I guess right now I'm just curious re: what others have experienced. Because I have to wait a few months to see a Dr, I decided to remove gluten, dairy, and nightshades again to see if it helps at all.
2023.06.04 21:44 Melodic-Translator45 Inverse and plaque psoriasis together
Hiya y'all. The labs just came back to confirm that I have both types. I'm seeing the derm to start biologic soon. My question is about the inverse psoriasis which troubles me way more than the plaque because I'm fat and it's all under my boobs and in my groin. I'm wondering if other people have both and how they handle it. Also will the areas that crust, crack and bleed scar permanently?
submitted by Melodic-Translator45 to Psoriasis [link] [comments]
2023.06.04 20:43 SweetBoy3D Otezla and Alcohol
24M here, just got started on Otezla ~7 weeks ago for my moderate plaque psoriasis. I’ve had some unpleasant gastrointestinal side effects that still haven’t fully subsided, but my skin is already starting to clear up in a pretty miraculous way.
Anyway, that’s not what I’m here to talk about today. I’m curious if anyone else has noticed a bizarre shift in their relationship with alcohol while taking Otezla.
I drink every weekend, often socially but sometimes just to unwind. I’m as happy to be out at a bar with friends as I am to be posted up on the couch with a six-pack watching basketball. Long story short, I like to drink and it’s a consistent part of my weekly routine.
Since starting on Otezla, though, drinking simply… doesn’t feel as good? It’s hard to pin down and describe exactly what about the experience is diminished, but essentially it’s just not as fun to be be drunk anymore. Makes me more headachey, maybe. I feel like even the taste is less appealing than it once was.
I’ve read online that apremilast is undergoing clinical trials for treatment of alcohol use disorder, after early findings that it was effective in curbing excessive alcohol consumption, so I guess my experience makes sense. The research only mentioned subjects’ reduced cravings while on the drug, though, nothing about its effect on the experience of drinking itself.
Just wondering if others have had a similar experience with this drug, can’t seem to find any discussion online re: this strange side effect. Personally I’m not complaining lol, I don’t think alcohol is a net positive on most people’s lives, myself included. I’ll probably just take this as an opportunity to cut down. Still, not a side effect I was expecting to say the least!
submitted by SweetBoy3D to Psoriasis [link] [comments]
Anyway, that’s not what I’m here to talk about today. I’m curious if anyone else has noticed a bizarre shift in their relationship with alcohol while taking Otezla.
I drink every weekend, often socially but sometimes just to unwind. I’m as happy to be out at a bar with friends as I am to be posted up on the couch with a six-pack watching basketball. Long story short, I like to drink and it’s a consistent part of my weekly routine.
Since starting on Otezla, though, drinking simply… doesn’t feel as good? It’s hard to pin down and describe exactly what about the experience is diminished, but essentially it’s just not as fun to be be drunk anymore. Makes me more headachey, maybe. I feel like even the taste is less appealing than it once was.
I’ve read online that apremilast is undergoing clinical trials for treatment of alcohol use disorder, after early findings that it was effective in curbing excessive alcohol consumption, so I guess my experience makes sense. The research only mentioned subjects’ reduced cravings while on the drug, though, nothing about its effect on the experience of drinking itself.
Just wondering if others have had a similar experience with this drug, can’t seem to find any discussion online re: this strange side effect. Personally I’m not complaining lol, I don’t think alcohol is a net positive on most people’s lives, myself included. I’ll probably just take this as an opportunity to cut down. Still, not a side effect I was expecting to say the least!
2023.06.04 03:46 jaysonm007 What is a good moisturizer for scalp psoriasis?
My scalp psoriasis is dying down to the point where I don't have to use topical steroids. Now my scalp just seems really dry with very few raised plaque patches. I would like to try a moisturizer. I know of vaseline/petroleum jelly for the areas just outside the hair but what works on the scalp itself?
I don't mind if my hair looks a bit greasier just as long as it isn't absolutely ridiculous (like I know I can't use Vaseline as it would look crazy). So if it makes me look like a greaser from the 1950's that is okay -- I just want to get rid of this. Any suggestions?
submitted by jaysonm007 to Psoriasis [link] [comments]
I don't mind if my hair looks a bit greasier just as long as it isn't absolutely ridiculous (like I know I can't use Vaseline as it would look crazy). So if it makes me look like a greaser from the 1950's that is okay -- I just want to get rid of this. Any suggestions?
2023.06.03 20:34 MajestaMajorca An article today about possible "causes."
https://www.medicalnewstoday.com/articles/researchers-investigate-what-causes-psoriasis-and-how-it-spreads?apid=38930495&rvid=c443f02fc5f6c738ae0aa2dedb868a4e3a6da33d16de577140226224a8f32b4d
"Among the study’s surprising findings were increased genetic activity in dozens of molecular pathways associated with the control of metabolism and lipid levels, which are associated with the development of diabetes and cardiovascular disease.
“Our molecular cartography unexpectedly revealed that even skin areas far away from plaques that look healthy have profound changes in their cellular and molecular makeup,” Dr. Naik explained."
submitted by MajestaMajorca to FreedomFromPsoriasis [link] [comments]
"Among the study’s surprising findings were increased genetic activity in dozens of molecular pathways associated with the control of metabolism and lipid levels, which are associated with the development of diabetes and cardiovascular disease.
“Our molecular cartography unexpectedly revealed that even skin areas far away from plaques that look healthy have profound changes in their cellular and molecular makeup,” Dr. Naik explained."
2023.06.03 20:32 MajestaMajorca Science paying a little more attention, maybe?
https://www.medicalnewstoday.com/articles/researchers-investigate-what-causes-psoriasis-and-how-it-spreads?apid=38930495&rvid=c443f02fc5f6c738ae0aa2dedb868a4e3a6da33d16de577140226224a8f32b4d
"Among the study’s surprising findings were increased genetic activity in dozens of molecular pathways associated with the control of metabolism and lipid levels, which are associated with the development of diabetes and cardiovascular disease.
“Our molecular cartography unexpectedly revealed that even skin areas far away from plaques that look healthy have profound changes in their cellular and molecular makeup,” Dr. Naik explained."
submitted by MajestaMajorca to Psoriasis [link] [comments]
"Among the study’s surprising findings were increased genetic activity in dozens of molecular pathways associated with the control of metabolism and lipid levels, which are associated with the development of diabetes and cardiovascular disease.
“Our molecular cartography unexpectedly revealed that even skin areas far away from plaques that look healthy have profound changes in their cellular and molecular makeup,” Dr. Naik explained."
2023.06.03 16:04 SeaAwareness3650 Celebrex --> Otezla --> Humira --> ???
I was diagnosed with PsA a couple years ago after being told for many years that I had osteoarthritis + eczema. I had a hip replacement at age 40 and kept asking, "How do I have such severe osteoarthritis at such a young age?" Whenever I asked about possibly having autoimmune arthritis, I was always told no. Since then I've had the second hip replaced and, due to increasing pain (especially in my left heel, elbow, both feet, hands) and horrible "eczema", I was finally diagnosed with PsA. I'd been on Celebrex for years for the "osteoarthritis", then after the PsA diagnosis they added Otezla. Otezla didn't seem to help at all, and it gave me insomnia. So the rheum switched me to Humira. Humira cleared up my worst skin issue by about 50%, but it didn't do much for my joint pain and it made me feel awful. The day of the shot I had to prepare for at least two more days of severe exhaustion. After three months on Humira I developed an intestinal issue (bloodwork all came back normal, no c-diff, no parasite, no salmonella) that they still don't understand, and I had to stop the Humira during that time because I was put on an antibiotic. Now I don't want to restart the Humira, because TBH I feel better without it. I do need to take something, though, so hoping there's a med that will give me relief.
For me the heel/foot pain and fatigue are the worst aspects of this disease so far, and my scalp psoriasis is extreme to the point where I have scabs under my hair everywhere (prescription shampoo doesn't help much). I am not working and left my last job because the stress caused flares so bad I could barely use my hands. I can't stand up for long periods, I can't sit for long periods (because when I stand up I can barely walk), and I can't use my hands all day (i.e., typing) either, especially if under stress. It's very difficult to find a job I can physically handle.
I guess there isn't really a question here, just venting and hoping for a better med.
submitted by SeaAwareness3650 to PsoriaticArthritis [link] [comments]
For me the heel/foot pain and fatigue are the worst aspects of this disease so far, and my scalp psoriasis is extreme to the point where I have scabs under my hair everywhere (prescription shampoo doesn't help much). I am not working and left my last job because the stress caused flares so bad I could barely use my hands. I can't stand up for long periods, I can't sit for long periods (because when I stand up I can barely walk), and I can't use my hands all day (i.e., typing) either, especially if under stress. It's very difficult to find a job I can physically handle.
I guess there isn't really a question here, just venting and hoping for a better med.
2023.06.02 19:28 LaGrippeResearchAlex Mild Psoriasis (PsO) Research Project
My name is Maggie and I am with LaGrippe Research, a market research firm specializing in healthcare. We are currently inviting individuals diagnosed with Mild Plaque Psoriasis (PsO) to participate in our upcoming discussion and want to see if you would be interested.
This will be in the form of a 2-part project. The first will be a 60-minute discussion with our moderator the week of June 26th, followed by a 2-day online community that will take place the week of July 10th. For participating in BOTH parts, you will be compensated $150 as a thank you. Payment for participating in both parts will be processed after the second part has been completed.
If you are interested, please fill out our preliminary questions online here: https://www.surveymonkey.com/PFJCKR3
If you have any questions, please contact Maggie at 847-373-4104 or email [[email protected]](mailto:[email protected])
submitted by LaGrippeResearchAlex to Psoriasis [link] [comments]
This will be in the form of a 2-part project. The first will be a 60-minute discussion with our moderator the week of June 26th, followed by a 2-day online community that will take place the week of July 10th. For participating in BOTH parts, you will be compensated $150 as a thank you. Payment for participating in both parts will be processed after the second part has been completed.
If you are interested, please fill out our preliminary questions online here: https://www.surveymonkey.com/PFJCKR3
If you have any questions, please contact Maggie at 847-373-4104 or email [[email protected]](mailto:[email protected])
2023.06.02 18:05 Student_Ok Changing services connected disability due to misdiagnosis during active duty
While active duty, I was diagnosed with dermatitis. I got that service connected at 0%. I still have this same rash but now it's worse. Through VA community care, my dermatologist is saying it's actually plaque psoriasis.
Has anybody ever been misdiagnosed while active duty and had to change their service connected disability afterwards?
submitted by Student_Ok to Veterans [link] [comments]
Has anybody ever been misdiagnosed while active duty and had to change their service connected disability afterwards?
2023.06.01 20:48 jigeshapunj31 Plaque Psoriasis Medication
Used propysalic for my Plaque Psoriasis but it left very dark scars around my feet up to my ankle I used propysalic for plaque psoriasis in my feet, it did get a little better but it left a very bad pigmentation all around my feet up till my ankle. It was quite dark and that darkened skin felt like dead skin that I could just peel off. Any idea what exactly happened? and How should I tell this to my derma?
submitted by jigeshapunj31 to Psoriasis [link] [comments]